diff --git a/src/microdot.py b/src/microdot.py
index f277c73..06e84d9 100644
--- a/src/microdot.py
+++ b/src/microdot.py
@@ -309,9 +309,10 @@ class Response():
     }
     send_file_buffer_size = 1024
 
-    def __init__(self, body='', status_code=200, headers=None):
+    def __init__(self, body='', status_code=200, headers=None, reason=None):
         self.status_code = status_code
         self.headers = headers.copy() if headers else {}
+        self.reason = reason
         if isinstance(body, (dict, list)):
             self.body = json.dumps(body).encode()
             self.headers['Content-Type'] = 'application/json'
@@ -364,9 +365,10 @@ class Response():
         self.complete()
 
         # status code
+        reason = self.reason if self.reason is not None else \
+            ('OK' if self.status_code == 200 else 'N/A')
         stream.write('HTTP/1.0 {status_code} {reason}\r\n'.format(
-            status_code=self.status_code,
-            reason='OK' if self.status_code == 200 else 'N/A').encode())
+            status_code=self.status_code, reason=reason).encode())
 
         # headers
         for header, value in self.headers.items():
diff --git a/src/microdot_asyncio.py b/src/microdot_asyncio.py
index 0425f1e..e3c6ea7 100644
--- a/src/microdot_asyncio.py
+++ b/src/microdot_asyncio.py
@@ -74,9 +74,10 @@ class Response(BaseResponse):
         self.complete()
 
         # status code
+        reason = self.reason if self.reason is not None else \
+            ('OK' if self.status_code == 200 else 'N/A')
         await stream.awrite('HTTP/1.0 {status_code} {reason}\r\n'.format(
-            status_code=self.status_code,
-            reason='OK' if self.status_code == 200 else 'N/A').encode())
+            status_code=self.status_code, reason=reason).encode())
 
         # headers
         for header, value in self.headers.items():
diff --git a/tests/microdot/test_response.py b/tests/microdot/test_response.py
index 7563c06..46a950c 100644
--- a/tests/microdot/test_response.py
+++ b/tests/microdot/test_response.py
@@ -112,6 +112,28 @@ class TestResponse(unittest.TestCase):
         self.assertEqual(res.headers, {'X-Test': 'Foo'})
         self.assertEqual(res.body, b'foo')
 
+    def test_create_with_reason(self):
+        res = Response('foo', reason='ALL GOOD!')
+        self.assertEqual(res.status_code, 200)
+        self.assertEqual(res.headers, {})
+        self.assertEqual(res.reason, 'ALL GOOD!')
+        self.assertEqual(res.body, b'foo')
+        fd = io.BytesIO()
+        res.write(fd)
+        response = fd.getvalue()
+        self.assertIn(b'HTTP/1.0 200 ALL GOOD!\r\n', response)
+
+    def test_create_with_status_and_reason(self):
+        res = Response('not found', 404, reason='NOT FOUND')
+        self.assertEqual(res.status_code, 404)
+        self.assertEqual(res.headers, {})
+        self.assertEqual(res.reason, 'NOT FOUND')
+        self.assertEqual(res.body, b'not found')
+        fd = io.BytesIO()
+        res.write(fd)
+        response = fd.getvalue()
+        self.assertIn(b'HTTP/1.0 404 NOT FOUND\r\n', response)
+
     def test_cookies(self):
         res = Response('ok')
         res.set_cookie('foo1', 'bar1')
diff --git a/tests/microdot_asyncio/test_response_asyncio.py b/tests/microdot_asyncio/test_response_asyncio.py
index 7a72aae..266fe0e 100644
--- a/tests/microdot_asyncio/test_response_asyncio.py
+++ b/tests/microdot_asyncio/test_response_asyncio.py
@@ -85,6 +85,26 @@ class TestResponseAsync(unittest.TestCase):
         self.assertIn(b'Content-Type: application/json\r\n', fd.response)
         self.assertTrue(fd.response.endswith(b'\r\n\r\n[1, "2"]'))
 
+    def test_create_with_reason(self):
+        res = Response('foo', reason='ALL GOOD!')
+        self.assertEqual(res.status_code, 200)
+        self.assertEqual(res.headers, {})
+        self.assertEqual(res.reason, 'ALL GOOD!')
+        self.assertEqual(res.body, b'foo')
+        fd = FakeStreamAsync()
+        _run(res.write(fd))
+        self.assertIn(b'HTTP/1.0 200 ALL GOOD!\r\n', fd.response)
+
+    def test_create_with_status_and_reason(self):
+        res = Response('not found', 404, reason='NOT FOUND')
+        self.assertEqual(res.status_code, 404)
+        self.assertEqual(res.headers, {})
+        self.assertEqual(res.reason, 'NOT FOUND')
+        self.assertEqual(res.body, b'not found')
+        fd = FakeStreamAsync()
+        _run(res.write(fd))
+        self.assertIn(b'HTTP/1.0 404 NOT FOUND\r\n', fd.response)
+
     def test_send_file(self):
         res = Response.send_file('tests/files/test.txt',
                                  content_type='text/html')