diff --git a/ports/rp2/CMakeLists.txt b/ports/rp2/CMakeLists.txt
index ed7202fb5..e58fc00fd 100644
--- a/ports/rp2/CMakeLists.txt
+++ b/ports/rp2/CMakeLists.txt
@@ -479,15 +479,6 @@ if (MICROPY_PY_NETWORK_WIZNET5K)
     )
 endif()
 
-if (MICROPY_PY_BTREE)
-    target_link_libraries(${MICROPY_TARGET} micropy_extmod_btree)
-    target_compile_definitions(${MICROPY_TARGET} PRIVATE
-        MICROPY_STREAMS_POSIX_API=1
-        MICROPY_BERKELEY_DB_DEFPSIZE=1024
-        MICROPY_BERKELEY_DB_MINCACHE=3
-    )
-endif()
-
 # Add qstr sources for extmod and usermod, in case they are modified by components above.
 list(APPEND MICROPY_SOURCE_QSTR
     ${MICROPY_SOURCE_EXTMOD}
@@ -581,7 +572,6 @@ set_source_files_properties(
 )
 
 target_compile_definitions(${MICROPY_TARGET} PRIVATE
-    ${MICROPY_DEF_CORE}
     ${MICROPY_DEF_BOARD}
     FFCONF_H=\"${MICROPY_OOFATFS_DIR}/ffconf.h\"
     LFS1_NO_MALLOC LFS1_NO_DEBUG LFS1_NO_WARN LFS1_NO_ERROR LFS1_NO_ASSERT